Dr Jay Newby

eMail: newby.23@mbi.osu.edu



The intricate machinery of a living cell must function even when subjected to thermal fluctuations. The effect of thermal fluctuations on a molecule is best described as random time dependent perturbations. Cellular processes are modeled by stochastic processes. While thermal fluctuations can be disruptive, it is more often the case that a cell uses the resulting randomness to its advantage. One example is Brownian motion, or diffusion, used to transport small molecules throughout the cell. The central motivation of my research is to understand how cells harness their intrinsic stochasticity.

Selected Publications: 
  • JN. and M. Schwemmer. Effects of moderate noise on a limit cycle oscillator: Counterrotation and bistability. Phys. Rev. Lett., 112:114101, 2014. preprint, abstract

  •  JN, P. C. Bressloff, and J. P. Keener. Breakdown of fast-slow analysis in an excitable system with channel noise. Phys. Rev. Lett., , 111:128121, 2013 preprint, abstract

  • S. Isaacson and JN. Uniform asymptotic approximation of diffusion to a small target.  Phys. Rev. E, 88:012820, 2013 preprint, abstract

  • JN and J. Chapman. Metastable behavior in Markov processes with internal states.  J. Math. Biol., 2013 preprint, abstract

  • P. C. Bressloff and JN. Stochastic models of intracellular transport.  Rev. Mod. Phys., 85:135-196, 2013 preprint, abstract

  • JN.  Isolating intrinsic noise sources in a stochastic genetic switch.  Physical Biol., 9:026002, 2012 preprint, abstract

Full Publication List