Jay Newby

Dr Jay Newby


eMail: newby [dot] 23 [-at-] mbi [dot] osu [dot] edu


Research Interests: 

Often we hear claims that stochastic effect are significant, particularly in models of biological phenomena. But how are they significant? What does the stochastic model tell us that a deterministic model cannot? The intricate machinery of a living cell must function even when subjected to thermal fluctuations. These thermal fluctuations are well described by a stochastic process, called noise, which can take many different forms. While noise can be detrimental, it is also possible that a cell sometimes uses noise to its benefit. One example is using Brownian motion, or diffusion, to transport small molecules throughout the cell. The central motivation of my research is to discover how cells take advantage of noise to do things they could not do otherwise.

Selected Publications: 
  • JN. and M. Schwemmer. Effects of moderate noise on a limit cycle oscillator: Counterrotation and bistability. Phys. Rev. Lett., 112:114101, 2014. preprint, abstract

  •  JN, P. C. Bressloff, and J. P. Keener. Breakdown of fast-slow analysis in an excitable system with channel noise. Phys. Rev. Lett., , 111:128121, 2013 preprint, abstract

  • S. Isaacson and JN. Uniform asymptotic approximation of diffusion to a small target.  Phys. Rev. E, 88:012820, 2013 preprint, abstract

  • JN and J. Chapman. Metastable behavior in Markov processes with internal states.  J. Math. Biol., 2013 preprint, abstract

  • P. C. Bressloff and JN. Stochastic models of intracellular transport.  Rev. Mod. Phys., 85:135-196, 2013 preprint, abstract

  • JN.  Isolating intrinsic noise sources in a stochastic genetic switch.  Physical Biol., 9:026002, 2012 preprint, abstract

Full Publication List