Brandilyn Stigler

I am a Postdoctoral Fellow at the Mathematical Biosciences Institute at The Ohio State University. My research involves the development of a mathematical framework for the reverse engineering of biochemical systems. The models used in this work are time- and state-discrete finite dynamical systems, described by polynomial functions over a finite field. We have developed a novel algorithmic approach for reverse engineering, with tools from computational algebra. This approach uses Groebner-basis techniques to build the set of all finite dynamical systems that fit time series data and to select minimal models from this set. The method has been specifically designed for experimental data from biochemical networks, where the data may take the form of time series of mRNA, protein, and/or metabolite concentrations. This work is currently being applied to an oxidative stress response network in S. cerevisiae and a developmental network in C. elegans embryo.

Contact Information

Mathematical Biosciences Institute The Ohio State University 250 Mathematics Building 231 West 18th Avenue Columbus, OH 43210

Phone: (614) 688-3292 Fax: (614) 247-6643 Email: bstigler at mbi . osu . edu

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Research Interests

Systems biology Computational algebra

Reverse-engineering methods Polynomial maps over finite fields

Discrete models of biochemical networks Groebner bases of zero-dimensional ideals

Mentors

Winfried Just Helen Chamberlin

Department of Mathematics, Ohio University Department of Molecular Genetics, OSU

Education

2005 2002 1999

PhD. in Mathematics (Advisor: Reinhard Laubenbacher) M.S. in Mathematics B.S. in Mathematics

Virginia Tech New Mexico State University New Mexico State University

Blacksburg, Virginia Las Cruces, New Mexico Las Cruces, New Mexico

Friday, 12-Jan-2007 16:56:43 EST